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Timeline of treatment with CAW and behavioral experiments. Three cohorts of NRF2KO and WT mice were treated with CAW (2 g/L) at 5 months of age; the first group was cognitively tested at 6 months, the second at 12, and the third at 18. Following behavioral tests, mice were euthanized, and tissue was collected. Abbreviations: CAW, water extract of Centella asiatica; NRF2KO, nuclear factor erythroid 2-related factor 2 knockout; WT, wild type.
