Hippocampal ATP content is lower in aged NRF2KO mice than WT nice: (A) hippocampal ATP content declined with age in all mice but because the data were not normally distributed the statistical significance of longitudinal effects between groups could not be determined. (B) Nonparametric analysis of the 18-month cohort revealed a significant group difference between Wilcoxon rank sums as determined by a χ2 test (χ2 = 16.91, p < 0.001). n = 8–15 per group. Abbreviations: CAW, water extract of Centella asiatica; Ctrl, control; NRF2KO, nuclear factor erythroid 2-related factor 2 knockout; WT, wild type.