Table 5.
Histopathological diagnosis categorized as described in included studies, with concordance of 7T MRI with histopathology.
| Reference | Histopathological diagnosis, (N) | FCD | HS | Gliosis | Ganglioglioma | Other | Negative/no pathology | %-Concordance of 7T MRI and histopathology* | |
|---|---|---|---|---|---|---|---|---|---|
| De Ciantis et al (De Ciantis et al., 2016) 2016 | FCD IIa 2; FCD IIb 1; FCD IIIa 1; gliosis 4. | 4 | 4 | 50% | 4x 7T + and FCD 4x 7T- and gliosis |
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| Veersema et al (Veersema et al., 2016) 2016 | FCD Ib 1; FCD IIa 3; FCD IIb 2 | 6 | 67% | 4x 7T + and FCD 2x 7T- and FCD (IIa and IIb) |
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| Kwan et al (Kwan et al., 2016) 2016 | FCD 1; HS 4; gliosis 4; normal 1 | 1 | 4 | 4 | 1 | 80% | 4x 7T + and HS 3x 7T + and gliosis 3x 7T+, pathology disconcordant 1x 7T- and neg pathology |
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| Santyr et al (Santyr et al., 2016) 2016 | FCD 1; HS 4; gliosis 4; normal 1 | 1 | 4 | 4 | 1 | 80% | Same as Kwan et al. | ||
| Colon et al (Colon et al., 2016) 2016 | FCD IIa 1; FCD IIb 2; FCD IIIb 1; ganglioglioma 1; no pathology 1 | 4 | 1 | 1 | 80% | 4x 7T + and FCD 1x 7T suspected FCD, histopathology showed ganglioglioma |
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| Stefanits et al (Stefanits et al., 2017) 2017 | ILAE HS I 6; ILAE HS II 2; no HS 5 | 8 | 5 | 85% | 8x 7T + and HS 2x 7T + and neg pathology 3x 7T- and neg pathology |
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| Veersema et al (Veersema et al., 2017) 2017 | FCD IIa 3; FCD IIb 1; mild FCD 5; negative pathology 3; no pathology 1 | 9 | 4 | 75% | 8x 7T + and FCD 2x 7T + and neg pathology 1x 7T- and FCD 1x 7T- and neg pathology |
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| Colon et al (Colon et al., 2018) 2018 | FCD II 3; no pathology 2 | 3 | 2 | 67% | 2x 7T + and FCD 1x 7T- and FCD |
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| Feldman et al (Feldman et al., 2019) 2019 | FCD 1; ganglioglioma 1; other 1; no pathology 1 | 1 | 1 | 1 | 1 | 100% | 1x 7T + and FCD 1x 7T + and ganglioglioma 1x 7T + and other |
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| Bartolini et al (Bartolini et al., 2019) 2019 | FCD Ib 2; FCD IIa 4; FCD IIb 6 | 12 | 83% | 10x 7T + and FCD+, 2x 7T- and FCD+ (2x Ib) |
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| Wang et al (Wang et al., 2020) 2020 | FCD IIa 2; FCD IIb 5; mild FCD 9; other 2; no pathology 7 | 16 | 2 | 7 | 67% | 11x 7T + and FCD 1x 7T + and other 5x 7T- and FCD 1x 7T- and other |
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| After removing duplicates Total N (%) | 53 (54) | 12 (12) | 8 (8.1) | 2 (2.0) | 8 (8.1) | 16 (16) | 65 (75) | ||
NS = not specified. FCD = focal cortical dysplasia. ILAE = international league against epilepsy. HS = hippocampal sclerosis. 7T+ = 7T MRI positive. 7T− = 7T MRI negative.
*Concordance when the lesion found on 7T MRI was confirmed with histopathology.
§Hallmarks of FCD: transmantle sign, increased cortical thickness, blurred grey/white matter junction, increased signal on T2, decreased signal on T1 of the subcortical white matter and gyration anomalies.