Figure 7.

Ligand-induced GIPR endosomal trafficking. Ligand-induced co-localization of GIPR with Venus-Rab5⁺ early endosomes (A and B), Venus-Rab7⁺ late endosomes (C and D), and Venus-Rab11⁺ recycling endosomes (E and F). The + iAUC representation of vehicle and baseline-corrected temporal response to each agonist is expressed as mean ± SEM. Bonferroni's test, ∗p < 0.05, ∗∗p < 0.005, and ∗∗∗p < 0.0005 using one-way ANOVA vs GIP (1–42). Six independent experiments were performed with at least two technical replicates per group.