. 2020 Nov 11;185(3):741–758. doi: 10.1007/s10549-020-05991-x

Table 4.

Mean scores of QLQ-C30 and QLQ-BR23 functioning scales and symptom ratings by treatment arm

	Questionnaire time points				p value
	Baseline	Halfway CT	Before last cycle of CT	6 months after surgery	Time	Randomization	Time by randomization
EORTC-QLQ-C30
Global Health
Regular diet	80.5	70.3	59.2	75.8	<0.001	0.298	0.883
FMD	79.5	71.2	61.5	78.7	<0.001	0.298	0.883
Functioning scales
Physical functioning
Regular diet	93.7	81.9	68.8	82.8	<0.001	0.316	0.562
FMD	96.4	84.0	77.0	86.2	<0.001	0.316	0.562
Role functioning
Regular diet	90.1	66.1	52.4	74.1	<0.001	0.392	0.653
FMD	86.7	67.0	52.9	78.1	<0.001	0.392	0.653
Emotional functioning
Regular diet	75.3	80.7	73.4	78.1	0.048	0.215	0.631
FMD	69.9	80.2	78.4	80.0	0.048	0.215	0.631
Cognitive functioning
Regular diet	89.4	77.2	70.5	76.9	0.011	0.106	0.533
FMD	84.2	80.3	75.5	74.8	0.011	0.106	0.533
Social functioning
Regular diet	92.0	74.9	62.8	83.6	0.005	0.467	0.724
FMD	88.6	78.8	68.6	83.3	0.005	0.467	0.724
Symptoms
Fatigue
Regular diet	19.0	39.8	52.8	31.1	<0.001	0.154	0.393
FMD	23.0	39.3	43.5	28.9	<0.001	0.154	0.393
Nausea
Regular diet	4.3	15.5	5.9	2.5	<0.001	0.629	0.312
FMD	4.2	12.1	7.4	3.1	<0.001	0.629	0.312
Pain
Regular diet	11.5	15.8	22.9	17.3	<0.001	0.992	0.159
FMD	7.6	8.5	25.5	20.0	<0.001	0.992	0.159
Dyspnea
Regular diet	4.6	14.0	26.4	16.0	0.001	0.694	0.045
FMD	3.7	20.6	20.6	9.6	0.001	0.694	0.045
Insomnia
Regular diet	26.4	26.9	37.5	38.3	<0.001	0.068	0.246
FMD	32.7	19.4	39.2	31.1	<0.001	0.068	0.246
Appetite loss
Regular diet	9.8	17.5	29.9	7.4	<0.001	0.196	0.535
FMD	14.5	17.0	21.6	5.2	<0.001	0.196	0.535
Constipation
Regular diet	2.3	25.1	22.2	8.0	<0.001	0.654	0.826
FMD	2.4	23.0	16.7	8.1	<0.001	0.654	0.826
Diarrhea
Regular diet	6.9	7.0	10.4	1.2	<0.001	0.623	0.749
FMD	4.8	7.3	13.7	2.2	<0.001	0.623	0.749
Financial difficulties
Regular diet	2.9	9.9	11.8	6.2	0.807	0.981	0.014
FMD	3.8	8.5	5.9	14.1		0.981	0.014
EORTC-QLQ-BR23
Body image
Regular diet	89.9	78.8	65.1	78.4	<0.001	0.466	0.366
FMD	90.3	73.2	68.4	74.3	<0.001	0.466	0.366
Sexual functioning
Regular diet	77.0	81.9	86.8	73.0	<0.001	0.815	0.292
FMD	76.1	78.5	86.3	75.8	<0.001	0.815	0.292
Sexual enjoyment
Regular diet	58.1	44.4	43.1	55.9	0.001	0.554	0.040
FMD	56.1	49.5	42.9	48.7	0.001	0.554	0.040
Future perspective
Regular diet	42.0	34.5	45.8	40.7	0.184	0.579	0.085
FMD	47.9	40.1	37.3	38.5	0.184	0.579	0.085
Symptom scales
Side effects of systemic therapy
Regular diet	10.5	32.8	40.0	18.5	<0.001	0.378	0.817
FMD	9.6	31.9	35.9	16.5	<0.001	0.378	0.817
Upset by hair loss
Regular diet	16.7	32.6	31.1	50.0	0.003	0.465	0.187
FMD	33.3	36.8	31.4	40.0	0.003	0.465	0.187
Distress thermometer
Regular diet		5.21	6.27	6.17	0.468	0.358	0.465
FMD		5.16	5.53	5.98	0.468	0.358	0.465

P-values < 0.05 were considered significant

P time changes of QoL scores over time, P randomization differences in QoL between the two treatment groups (FMD vs. regular diet), P time by randomization different effects between treatment groups over time, CT chemotherapy, FMD fasting mimicking diet.