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. 2021 Mar 1;12(3):226. doi: 10.1038/s41419-021-03481-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Animal modeling of stretch-induced scarring in rat tail. B Images of scar appearances and elevations in the PBS-treated group and GsMTx4-treated group (Scale bar = 2 mm). C, D Images and quantitative analysis of cross-sections of scar in PBS-treated group and GsMTx4-treated group. (Scale bar = 500 μm). E, F Images and quantitative analysis of SEI of scars in PBS-treated group and GsMTx4-treated group. (Scale bar = 500 μm). The long arrow ‘D’ represents the thickness of hypertrophic scar tissues while the short arrow ‘d’ represents the thickness of adjacent normal skin tissues. “scar elevation index” is defined as the D/d ratio. G, H Images and quantitative analysis of collagen density of scars in PBS-treated group and GsMTx4-treated group. (Scale bar = 50 μm). Scale bars for the zoom images, 50 µm. I, J Images and quantitative analysis of α-SMA expression in PBS-treated group and GsMTx4-treated group. (Scale bar = 50 μm). Arterioles were excluded from α-SMA quantitation. The results are expressed as the means with SD (n = 6). T-test is used for all analysis. **P < 0.01, ***P < 0.005.