Fig. 6. The schematic diagram of mechanical stretch promotes HS formation through Piezo1.

During hypertrophic scar formation, mechanical force delivered from the extracellular matrix to Piezo1, which localizes at cell membranes of dermal fibroblasts. Then, mechanical force triggers Piezo1 overexpression and Piezo1-mediated calcium concentration in dermal fibroblasts. In addition, Piezo1 activity promotes proliferation, migration, and differentiation of dermal fibroblasts in response to mechanical force, subsequently contributing to mechanical force-induced hypertrophic scar formation.