Table 1.

Protein expression of CB2Rs in the CNS.

Brain region	Cell types	Subcellular localization	Species	Ref
Olfactory tubercle	Neurons		Healthy SD rats	[25]
Cerebral cortex: (layers III and v)	Pyramidal neurons	Cell body and apical dendrite	Healthy SD rats	[25]
Hippocampus: CA1 CA2, CA3 and subiculum	Neurons Gila cells Endothelial cells Pyramidal neurons	Cell body and dendrite Plasma membrane Plasma membrane	Healthy SD rats Healthy SD rats Healthy SD rats Healthy SD rats	[26, 29] [26, 29] [26, 29] [25]
Thalamus		Cell body	Healthy SD rats	[25]
Hypothalamus		Cell body	Healthy SD rats	[25]
Midbrain: (periaqueductal gray, paratrochlear nucleus, paralemniscal nucleus, red nucleus, amygdala, geniculate nucleus and interpeduncular nucleus, inferior colliculus, substantia nigra)	Neurons Glial and endothelial cells	Cell body and dendrite Plasma membrane and some unmyelinated axons	Healthy SD rats Healthy SD rats	[25, 26] [26]
Pons: (pontine nucleus)	Astrocytes or microglial cells	Cell processes	Healthy SD rats	[25]
Medulla:	Neurons	Cell body	Healthy SD rats	[25]
Brain stem:	Neurons		Healthy wistar rats, ferret	[28, 30]
Cerebellum: (molecular layers. Purkinje cell layers, the granule layers)	Neurons Endothelial cells Perivascular microglial cells	Cell body and dendrite	Healthy rats, ferret Healthy rats Post-mortem brain	[25, 30] [27] [31]
Retina: (segment of photoreceptor Layer, Outer nuclear layer, Henle fiber layer, outer plexiform layer, inner nuclear layer, inner plexiform layer, ganglion cell layer)	Cones Rods Müller cells Horizontal cells Rod bipolar cells Cone bipolar cells Amacrine cells Ganglion cells	Cell body Cell body Cell fiber Soma and dendrite Soma and dendrite Soma Soma Soma and nuclei	Healthy mice Healthy mice Healthy SD rats and monkeys Healthy mice Healthy mice Healthy mice Healthy mice Healthy mice and monkey	[150] [150] [151, 152] [150] [150] [150] [150] [150, 152]