Table 2.

mRNA expression of CB2Rs in the CNS.

Brain region	Cell types	Subcellular location	Species	Ref
Prefrontal cortex			Healthy mice and rat	[35, 37]
Cerebral cortex: (layers III and V)	Neurons with pyramidal-like phenotype		Healthy mice, rat and Macaca fascicularis	[35, 37, 153]
Hippocampus: (CA1, CA3 and dentate gyrus)	Glutamatergic neurons GABAergic interneurons Pyramidal neurons	Nuclei Nuclei Cell body	Healthy mice and Macaca fascicularis Healthy mice and Macaca fascicularis Healthy mice	[38, 153] [38, 153] [38]
Hypothalamus			Healthy mice	[35]
Striatum			healthy rats, control mice and LPS-injected mice	[35, 37, 39]
Globus pallidus: (internal and external segments)	Pallidal neurons Pallidothalamic projection neurons	Cytoplasm Cell body	Healthy Macaca fascicularis control, parkinsonian and dyskinetic monkeys	[153, 154]
Nucleus accumbens			Human with developmental disorders, healthy rat and mice	[35, 37]
Amygdal			Human with developmental disorders,	[35]
Putaman			Human with developmental disorders,	[35]
Caudate			Human with developmental disorders,	[35]
Substantia nigra	Microglial cells		Post-mortem PD patients and control subjects	[39]
Ventral tegmental area	TH-positive DA neurons DAT-positive DA neurons TH-negative non-DA neurons		Healthy mice, Healthy rat Healthy mice	[32, 37] [37] [32]
Brain stem	Neurons of the dorsal motor nucleus of the vagus	Cell membrane and cytoplasm	Healthy Ferret, rat and mice	[30, 35]
Cerebellum	Cerebellar granule cells		Healthy Ferret, rat and mice	[30, 35]
Retina: (inner segments of photoreceptor cells, inner nuclear layer, retinal ganglion cell layer)	Retina ganglion cells	Soma	Healthy adult SD rats	[41]