Fig. 2.

Puerarin protects against OVX plus AAC-induced cardiac hypertrophy, as indicated by echocardiographic examinations. a Representative M-mode images of the indicated groups. b–d Parameters of cardiac structure. LVPW left ventricular posterior wall diameter, LVAW left ventricular anterior wall diameter, LVID left ventricular internal dimension. E: Left ventricular function changes in ejection fraction (LVEF) and fractional shortening (LVFS). OVX ovariectomy, AAC abdominal aortic constriction group; OVX + AAC + Pue, puerarin injected-OVX + AAC group; OVX + AAC + E2, E2 injected-OVX + AAC group; OVX + AAC + Fen, fenofibrate injected-OVX + AAC group. Data are presented as the mean ± SD. Statistical significance was determined using one-way ANOVA coupled with Tukey’s multiple comparison post hoc test. ^*P < 0.05 vs. sham group; ^#P < 0.05 vs. OVX + AAC group, n = 6–8 rats per group