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. 2021 Feb 16;7:599332. doi: 10.3389/fmolb.2020.599332

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Copyright © 2021 Fouad, Hauton and D'Angiolella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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E2F1: roles as a cause and a consequence of DNA replication stress (“DNA RS” in figure). (A) E2F1 functions upstream and downstream of DNA replication stress. Highlighted in the figure are E2F1-engaging pathways downstream of the DNA RS response when oncogenic and tumor suppressor signaling pathways are intact (light blue), and upstream of DNA RS when oncogenic and/or tumor suppressor signaling pathways are altered (light pink). (B) Consequences of abrogating the E2F1 post-translational regulatory triad comprising Chk1, Rb, and cyclin F. Created with BioRender.com.