Table 2.
Measured quantities and their relation to model components.
| Measurement | Model output | Equation | Unit |
|---|---|---|---|
| Hepatic triglyceride | y1 | [x4] + [x5] + [x6] + [x7] | μ mol/liver |
| Hepatic cholesteryl ester | y2 | [x2] + [x3] | μ mol/liver |
| Hepatic free cholesterol | y3 | [x1] | μ mol/liver |
| Plasma total cholesterol | y4 | [x9] + [x10] | μ mol/L |
| HDL-cholesterol | y5 | [x10] | μ mol/L |
| Plasma triglyceride | y6 | [x8] | μ mol/L |
| Plasma free fatty acid | y7 | [x11] | μ mol/L |
| VLDL TG/C ratio | y8 | TGcnt/CEcnt | [-] |
| VLDL diameter | y9 | DVLDL | nm |
| VLDL-TG production | y10 | f14 | μ mol/h |
| VLDL catabolic rate | y11 | CRVLDL | [-] |
| de novo lipogenesis | y12 | FCDNL | [-] |
| Hepatic HDL-C uptake | y13* | f21 | μ mol/h |
| Ratio cyt-TG / ER-TG concentration | y14* | RcTGcyt, TGer | [-] |
| Ratio cyt-TG / ER-TG production | y15* | RpTGcyt, TGer | [-] |
*
Only for the untreated phenotype (t = 0).