Fig. 3. A novel HuR inhibitor KH-3 disrupts HuR-mRNA interaction, and inhibits pancreatic cancer cell viability.
A. Chemical structure of KH-3. B. Inhibition of cell viability by KH-3. C. Upper: Western blot showing endogenous HuR levels of the tested cell lines. Lower: The correlation between HuR levels and the sensitivity of cells to KH-3 treatment. Bars show relative band density of HuR normalized to GAPDH, and the line shows IC50 values of KH-3.