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. 2021 Mar 2;10:7. doi: 10.1186/s13619-020-00070-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The connections between DNMT1 and TET1. a DNMT1 maintains DNA methylation during proliferation by methylating hemimethylated CpG sites into full-methylated. TET1 has higher abilities to demethylate hemimethylated CpG sites than full-methylated. b Passive DNA demethylation by inhibiting DNMT1 leads to lower increase in chromatin accessibility and gene expression than active DNA demethylation by stimulating TET1