Table 2.
Estimated cumulative glucocorticoid doses in a 24-week period for a 60 kg patient in different induction to remission schemes.
Regimen | Methylprednisolone total cumulative dose (g) | Oral prednisone total cumulative dose (g) | Oral prednisone average dose (mg/day) | Total GC dose (g) |
---|---|---|---|---|
Modified NIH, 2001 (76) | 9.00 | 2.84 | 16.9 | 11.8 |
ELNT, 2002 (77) | 2.25 | 3.12 | 18.5 | 5.37 |
ALMS, 2009 (85) | – | 4.27 | 25.4 | 4.27 |
MYLUPUS, 2011 (80) | 1.50 | 2.14 | 12.7 | 3.64 |
RITUXILUP, 2013 (86) | 1.00 | – | – | 1.00 |
LupusCRUCES, 2014 (48) | 1.50-3.00 | 1.30-1.50 | 8.0-9.0 | 2.80–4.50 |
Chinese multitarget, 2015 (81) | 1.5 | 3.25 | 16.2 | 4.75 |
4+2 Rituximab, 2015 (87) | 2.70 | 2.52 | 15.0 | 5.22 |
AURA-LV, 2019 (84) | 1.00 | 1.33 | 7.9 | 2.33 |
BLISS-LN, 2020 (88) | 0.50–3.00* | 3.12–4.27 | 18.5–25.4 | 3.12–4.27 |
NOBILITY, 2020 (89) | 0.75–3.00* | 1.79–1.93 | 10.6–11.5 | 1.79–1.93 |
Methylprednisolone pulses elective at discretion of the investigator.