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. 2021 Feb 16;12:635484. doi: 10.3389/fimmu.2021.635484

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Copyright © 2021 Long, Guan, Hu, Yang, He, Lin, Luo, Li, He, Du and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The molecular mechanisms of natural polyphenols in colon cancer. In colon cancer cells, natural polyphenols upregulate the expression of BCL and FADD protein and promote cell apoptosis. Natural polyphenols also downregulate PI3K/AKT and β-catenin signaling pathways and then hinder cell division. Moreover, natural polyphenols inhibit the activity of immune cells, regulate gut microbes leading to down-regulation of the NF-κB signaling pathway, thereby reducing the release of inflammatory factors, such as IL-6, IL-1β, and TNF-α (Red indicates promotion; blue indicates inhibition; black indicates regulation).