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. 2021 Feb 16;9:642930. doi: 10.3389/fcell.2021.642930

FIGURE 4.

FIGURE 4

Non-coding LIN28A mRNA promotes lung metastasis of colon cancer. (A) Over-expression of non-coding LIN28A mRNA promotes lung metastasis of colon cancer cells in vivo by using tail vein injection model (magnification, 20×; Scale bars, 500 μm; the black arrow represents the location of the metastasis). The expression of HIF1α and Ki67 in metastatic cancer tissues was evaluated by using immunohistochemistry (Scale bars, 200 μm for low-power field; 50 μm for high-power field). (B) LIN28A protein promotes metastasis of colon cancer cells in vivo (magnification, 20×; Scale bars, 500 μm; the black arrow represents the location of the metastasis.). The expression of HIF1α and Ki67 in metastatic cancer tissues was evaluated by using immunohistochemistry (Scale bars, 200 μm for low-power field; 50 μm for high-power field). The statistical significance was represented by *P < 0.05.