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. 2021 Mar 1;12:1355. doi: 10.1038/s41467-021-21601-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a mMED cryo-EM map at 4.0 Å resolution. b Local resolution in the mMED map points to high mobility of the Middle module and domains that form the CTD-binding gap. Slicing through the map highlights comparatively high (~3.5 Å) resolution throughout the core of the complex. c Mammalian Mediator molecular model. d Schematic representation of mMED’s modular organization and its interaction with RNA polymerase II (RNAPII, through the polymerase CTD) and the Cdk8 kinase module (CKM).