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. 2020 May 25;42(1):45–54. doi: 10.1038/s41401-020-0407-5

Fig. 3. Effect of the daily administration of 0 °C IW on neuropsychiatric changes in APP/PS1 mice.

Fig. 3

The open field test was used to observe the neuropsychiatric changes in wild-type C57BL/6 mice (W, n = 5) and APP/PS1 mice (AD model, A, n = 4) after they were administered intragastric water (IW, 10 mL/kg, 2 times/day) at a temperature of 0 °C (the W-0 °C and A-0 °C groups) or 25 °C (the W-25 °C and A-25 °C groups) for 35 consecutive days, and the total distance traveled (a), velocity (b), and distance traveled in the center zone (c) were recorded. Mean ± SEM; *P < 0.05, **P < 0.01, and ***P < 0.001.