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. 2020 May 25;42(1):45–54. doi: 10.1038/s41401-020-0407-5

Fig. 5. Effects of the daily administration of 0 °C IW on the balance of excitatory/inhibitory neurotransmitters.

Fig. 5

After the wild-type C57BL/6 mice (W, n = 5) and APP/PS1 mice (AD model, A, n = 4) were administered intragastric water (IW, 10 mL/kg, 2 times/day) at either 0 °C (the W-0 °C or A-0 °C group) or 25 °C (the W-25 °C and A-25 °C group) for 35 consecutive days, the concentrations of GABA (a) and glutamate (b) in cortical tissues were measured by ELISA, and the GABA and glutamate ratio was calculated (c). Mean ± SEM; *P < 0.05, **P < 0.01, and ***P < 0.001.