Table 1.
Baseline characteristics of study participants.
| Group | Study ID | Age | Gender | Dose | CD4 cells / microL | Screening Viral load (c/mL) | Baseline Viral Load (c/mL) | Screening Viral Outgrowth Assay (VOA)a | Screening PhenoSense mAb IC50 (μg/mL)b |
|---|---|---|---|---|---|---|---|---|---|
| HIV uninfected | 101 | 43 | Male | 3 mg/kg + trace | NA | NA | NA | NA | NA |
| 102 | 31 | Female | 3 mg/kg + trace | NA | NA | NA | NA | NA | |
| 103 | 56 | Female | Trace | NA | NA | NA | NA | NA | |
| 104 | 58 | Male | Trace | NA | NA | NA | NA | NA | |
| HIV Infected viremic mg/kg + trace' does the number 3 have its own line? this would be better if '3 mg/kg' was on one line of the cell and the next line of the cell was '+ trace'"?> | 201 | 49 | Male | NA | 600 | 65977 | NA | 0/4 (0%) | > 50 |
| 202 | 49 | Female | Trace | 377 | 33200 | 59052 | 7/10 (70%) | 0.20679 | |
| 203 | 42 | Male | 3 mg/kg + trace | 495 | 130187 | 76486 | 12/12 (100%) | 0.03503 | |
| 204 | 28 | Male | 3 mg/kg + trace | 1012 | 1239 | 331 | 59/62 (95%) | 0.03233 | |
| 205 | 57 | Male | NA | 557 | 79 | NA | NA | NA | |
| 206 | 61 | Male | Trace | 560 | 5649 | 6631 | 5/27 (19%)c | 0.70811 | |
| 207 | 41 | Male | Trace | 391 | 1656 | 651 | 8/8 (100%)d | 0.04288 | |
| 208 | 28 | Male | Trace | 840 | 27209 | 395598 | 13/35 (37%)d,e | 0.07172 | |
| Median (IQR) | 45.5 (37.8-51) | 559 (469 - 660) | 16429 (1552 - 41394) | 32841 (2146-72127) | |||||
| HIV infected aviremicf | 301 | 36 | Male | Trace | 468 | < 20 | < 20 | 4/5 (80%) | 0.04288 |
| 302 | 60 | Male | Trace | 451 | < 20 | < 20 | 10/10 (100%) | 0.02806 |
NOTES:
a
Reported as the number of wells sensitive to 3BNC117 as a proportion of the number of wells positive for virus
b
Concentration of antibody required to inhibit viral replication by 50%
c
Had additional wells considered partially sensitive to 3BNC117. 22/27 wells positive if these wells included
d
Using Aviremic VOA
e
including wells that were partially sensitive to 3BNC117, means that 27/35 wells were positive
f
3 individuals screened but not included for baseline analysis due to study termination and therefore were not included; NA, not applicable; IQR, interquartile range.