The KLB rs17618244 variant is associated with fibrosis in patients with MAFLD. Association of the KLB rs17618244 variant with steatosis (a), lobular inflammation (b) ballooning grade (c) and fibrosis stage (d) in MAFLD patients from the Hepatology service cohort (n = 1111). Multivariable ordinal regression analysis adjusted for age, sex, BMI, T2D, presence of PNPLA3 I148M, TM6SF2 E167K and MBOAT7 T alleles at additive model.