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. 2021 Feb 25;65:103249. doi: 10.1016/j.ebiom.2021.103249

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 3 — KLB mRNA levels are higher in patients who carry the at risk A allele and correlate with the expression of genes involved in fibrogenesis. KLB (a) and CYP7A1 (b) mRNA levels in carriers of the rs17618244 A allele compared to non-carriers. Correlation analyses between hepatic KLB gene expression and CYP7A1 (c), TGF-β (d), COL1A1 (e) and COL3A1 (f) mRNA levels evaluated by transcriptome analysis on liver biopsies (n = 125). Circulating levels of KLB (g) and FGF19 (h) in 175 NAFLD adult patients. Bar graphs represents KLB and FGF serum levels stratified according to the presence of the KLB at risk A allele (GG=59; GA/AA=116). Data were logarithmically transformed and analyzed by 2-tailed T-tests, Adjusted *p<0.05.