Fig. 7. Multiple pathways for RNA localization toward centrosome.

During quiescence, mother centriole tightly attaches to plasma membrane by distal appendages to nucleate the formation of primary cilia. To relay the signals from environment, several receptors are embedded at ciliary membrane. Centriolar satellites deliver components of centrosome and primary cilia. Centrosomal transcripts could be localized by ① EJC and/or other RNPs-mediated pathway, ② polysome-dependent pathway, and ③ polysome-dependent and EJC-dependent pathway.