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. 2021 Mar 1;11:4903. doi: 10.1038/s41598-021-84036-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of ex-vivo T2-weighted images of the murine cervix. (A) The transverse plane of murine endocervix (left) and ectocervix (right) are imaged in non-pregnant (NP) and pregnant mice during mid-gestation (GD15) and late gestation (GD18), indicating that the cervical tissue and canal become wider as labor approaches. Images were generated through MNI Display (McGill Centre for Integrative Neuroscience, version 2.0.6, http://www.bic.mni.mcgill.ca/software/Display/Display.html). The orange color indicate the level of tissue hydration (brighter colors indicates more hydrated regions). Scale bar = 1 mm. (B),(C) Width and volume measurements by MNI Display (McGill Centre for Integrative Neuroscience, version 2.0.6, http://www.bic.mni.mcgill.ca/software/Display/Display.html) are shown as mean ± SEM. Results confirm that at late gestation (GD18) the canal and tissue in the region of the endocervix (white bars) is significantly larger than in the ectocervix (black bars), and these parameters are significantly different from the NP cervix. Statistical significance was determined by two-way ANOVA with Bonferroni post-test. Letters indicate significant differences in the endocervix volume across gestation. Asterisks indicate differences between the endocervix and ectocervix from the same gestational day. *p < 0.05;**p < 0.01. (n = 3–4/GD).