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. 2021 Mar 1;11:4903. doi: 10.1038/s41598-021-84036-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images and quantification of hyaluronic acid binding protein (HABP) immunostaining in the murine endo- an ectocervix across gestation and term labor. (A) Shown are cross-sections of endocervix (left) and ectocervix (right) from non-pregnant (NP), pregnant (GD15, GD18, GD19), and laboring mice immunostained with antibody against HABP. Positive brown staining indicates presence of HABP. Blue shows hematoxylin counterstaining. Magnification is at 200×. Scale bar = 100 μm. (B) Quantification of HABP staining in the mouse cervix across gestation by image analysis using Visiopharm Software Engine (version 6.6.1.2572). Murine endocervixes (white bars) and ectocervixes (black bars). Data are presented as mean ± SEM. Statistical significance was determined by two-way ANOVA followed by Bonferroni post-test. Different lower case letters indicate significant differences in the endocervix across gestation, while different upper case letters indicate significant differences in the ectocervix across gestation. (n = 3–4/GD).