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. 2021 Mar 1;11:4903. doi: 10.1038/s41598-021-84036-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Smooth muscle actin (SMA), collagen type 1 (COL1) and hyaluronic acid binding protein (HABP) immunostaining within transverse sections of the non-pregnant and pregnant murine endocervix. Brown deposit indicate positive immunostaining. Blue shows hematoxylin counterstaining. Three zones are identified in both NP and GD19 samples: inner, middle and outer. (A) Staining of SMA is absent in the inner zone, while prominent in a middle zone (circular muscle fibers), and in an outer zone (longitudinal muscle fibers); (B) Staining of COL1 is localized in the sub-epithelial region of the inner zone specifically in the NP sample, but not in GD19 sample. (C) HABP shows similar weak staining throughout all three zones in NP endocervix, but the immunostaining is more intense in GD19 sample showing no heterogeneity. Magnification is at 200×. Scale bar = 100 μm.