Fig. 5. The predictive value of a genetic testing model based on common polymorphisms in an independent European case-control cohort.

The area under the receiver operating characteristic curve for the performance of a keratoconus predictive model that used the SNPs identified through the multi-ethnic analysis. The model was trained in the discovery populations of European ancestry and was replicated in a completely independent European panel of 222 keratoconus patients and 2208 controls.