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. 2021 Feb 13;73:105494. doi: 10.1016/j.ultsonch.2021.105494

Scheme 1.

Scheme 1

The diagram of PTMB binding to the cells and the enhanced calcium influx by US stimulation. PTMB was incubated with nerve cells, resulting in the binding of Piezo1-MBs to the Piezo1 channel. Before US stimulation, extracellular calcium concentration is higher than intracellular calcium concentration and the Piezo1 channel to which PTMB attached via receptor-ligand binding on the cell membrane is closed. US stimulation lead to the opening of Piezo1 channel, followed by extracellular calcium flowing into the cells.