Fig. 3.

The effects of global knockout of Metrnl on blood lipid parameters under a high-fat diet (HFD). a Body weights of Metrnl^−/− and wild-type mice (WT) fed a HFD (n = 8-9). b–f The effects of global knockout of Metrnl on high-density lipoprotein cholesterol (HDL-C, b), low-density lipoprotein cholesterol (LDL-C, c), total cholesterol (TC, d), total triglyceride (TG, e) and nonesterified fatty acid (NEFA, f) in circulation (n = 8–9). The mice were fed a HFD for 16 weeks. *P < 0.05; **P < 0.01 vs. WT