Fig. 4.

The effects of intestine-specific knockout of Metrnl on blood lipid parameters. a Body weights of intestine-specific Metrnl knockout (Intestine-Metrnl^−/−) and wild-type mice (WT) fed a normal chow diet (n = 7–9). b The effects of intestine-specific knockout of Metrnl on blood lipid parameters on a normal chow diet (n = 7–9). c Body weights of Intestine-Metrnl^−/− and WT mice fed a high-fat diet (HFD) for 16 weeks. d The effects of intestine-specific knockout of Metrnl on blood lipid parameters under a HFD for 16 weeks (n = 13–14). HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride; NEFA, nonesterified fatty acid