Fig. 7.

The effects of deficiency of liver Metrnl on VLDL release and expression of lipid synthetic and metabolic genes. a, b VLDL release was evaluated in Metrnl liver-specific knockout mice fed a normal chow diet (a) (n = 3) or a high-fat diet (HFD, b) (n = 3). c Expression of lipid synthesis and metabolic genes in Metrnl-deficient livers (n = 7). d Expression of lipid synthesis and metabolic genes in primary hepatocytes overexpressing Metrnl (Metrnl OE, n = 3–6)