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. 2021 Mar 1;11:4835. doi: 10.1038/s41598-021-83668-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DGE-PPI network. (a) It represents a gathering and merging of the DGE analysis results and the Human Protein–Protein Interaction network from the Mentha Database. Red lines represent the connections of the gatekeepers. Color scale is presented in the left top corner. It represents the color scale applied to show graphically the values in the centrality measure for each node in the networks. (b) The red lines represent the connections of the gatekeepers plus the connections of its first neighbors (direct connected nodes to gatekeepers). The red lines comprise most of the network connections. (a,b) The proteins with less connections are marked in yellow and the most connected proteins are marked in navy blue purple. The size of each node represents the value of the clustering centrality measure; The bigger, the more value it has.