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. 2020 Dec 10;124(5):963–974. doi: 10.1038/s41416-020-01198-5

Fig. 5. F. nucleatum confers chemoresistance by modulating autophagy in ESCC.

Fig. 5

a Western blot analysis of ATG7, LC3B and Beclin-1 expression in TE8 and TE10 cells transfected with siATG7 and co-cultured with F. nucleatum. Statistical significances are denoted by *P < 0.05, **P < 0.01, ***P < 0.001. b Proliferation assay in siATG7-transfected TE8 cells and TE10 cells co-cultured with F. nucleatum and treated with 5-FU, CDDP, and Docetaxel. *P < 0.05 (red and blue) indicates significant difference between the sictrl + ctrl and sictrl + FN groups and the siATG7 + ctrl and siATG7 + FN groups. c Immunohistochemical analysis of ATG7 protein expression in normal epithelial tissue and tumour lesions of ESCC patients. Higher F. nucleatum DNA was observed in the ATG7 high expression group (n = 59) compared to the low expression group (n = 225) (P = 0.0026).