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. 2020 May 25;42(1):149–159. doi: 10.1038/s41401-020-0419-1

Fig. 3. SMS2-selective inhibitor 15w attenuates M2 macrophage polarization.

Fig. 3

a The chemical structure of compound 15w. Molecular weight: 369.78. Molecular formula: C19H13ClFN3O2. b HPLC measurements of SMS2 enzyme inhibition by 15w in BMDMs. c Flow cytometry quantification of M2 macrophage polarization without or with 15w. d Real-time PCR was performed 24 h after IL-4-stimulated M2 polarization in BMDMs. e Immunoblotting of the indicated BMDMs 48 h after IL-4 stimulation. Data are presented as the mean ± SD of three representative experiments. **P < 0.01; ***P < 0.001.