Fig. 4. SMS2 inhibitor partially prevents TNBC cell-induced macrophage M2 polarization.

a, b Conditioned medium (CM) from 4T1 or MDA-MB-231 cells was used to culture BMDMs without or with 15w for 24 h, and then the cells were analyzed by flow cytometry. c, d The levels of secreted cytokines were measured by ELISA 48 h later. Data are presented as the mean ± SD of three representative experiments. **P < 0.01; ***P < 0.001; ****P < 0.0001.