Table 1.
Sociodemographic, clinical and histological features of KRAS+versus KRAS-cases
| Feature | KRAS+(n=28), n(%) | KRAS− (n=72), n(%) | P |
|---|---|---|---|
| Age(years) | |||
| <40 | 4(14.3) | 6(8.33) | 0.372 |
| >40 | 24(85.7) | 66(91.67) | |
| Gender | |||
| Male | 16(57.14) | 49(68.06) | 0.304 |
| Female | 12(42.86) | 23(31.94) | |
| Site of biopsy | |||
| Respiratory tree | 25(89.29) | 63(87.5) | 0.805 |
| Metastatic site | 3(10.71) | 9(12.5) | |
| Smoking history | |||
| Smoker/ex-smoker | 9(32.14) | 28(38.89) | 0.530 |
| Nonsmoker | 19(67.86) | 44(61.11) | |
| Educational status | |||
| Primary | 10(35.71) | 18(25) | 0.599 |
| Metric | 5(17.85) | 11(15.2) | |
| Higher/graduate | 2(7.14) | 10(13.88) | |
| Illiterate | 11(39.28) | 33(45.83) | |
| Economical class | |||
| Poor | 19(67.85) | 53(73.61) | 0.841 |
| Middle/upper middle | 4(14.28) | 8(11.11) | |
| Lower | 5(17.85) | 11(15.27) | |
| Histological phenotype-(presence of squamous differentiation) | |||
| Adenocarcinoma with squamous differentiation(primary and metastatic) | 1(3.57) | 3(4.17) | 0.891 |
| Adenocarcinoma with the absence of squamous differentiation(primary and metastatic) | 27(96.43) | 69(95.83) | |
| TTF-1 | |||
| Positive | 25(89.29) | 61(84.72) | 0.554 |
| Negative | 3(10.71) | 11(15.28) | |
| Napsin-A | |||
| Positive | 26(92.86) | 62(86.11) | 0.351 |
| Negative | 2(7.14) | 10(13.89) | |
| T stage(n=65) | |||
| T1 | 0(0) | 3(6.67) | 0.402 |
| T2 | 5(25) | 6(13.33) | |
| T3 | 4(20) | 17(37.78) | |
| T4 | 11(55) | 19(42.22) | |
| N stage(n=65) | |||
| N0 | 8(40) | 13(28.89) | 0.478 |
| N1 | 2(10) | 11(24.44) | |
| N2 | 7(35) | 17(37.78) | |
| N3 | 3(15) | 4(8.89) | |
| M stage(n=65) | |||
| M0 | 9(45) | 24(53.33) | 0.535 |
| M1 | 11(55) | 21(46.67) | |
| Clinical stage(n=65) | |||
| I | 0(0) | 1(2.22) | 0.682 |
| II | 3(15) | 4(8.89) | |
| III | 6(30) | 19(42.22) | |
| IV | 11(55) | 21(46.67) | |
| Survival(n=72) | |||
| Up to 3 months | 3(15.79) | 14(26.42) | 0.636 |
| >3 months–6 months | 6(31.58) | 10(18.86) | |
| >6 months–12 months | 7(36.84) | 20(37.74) | |
| >12 months | 3(15.79) | 9(16.98) |
KRAS: Kirsten rat sarcoma virus, TTF: Thyroid transcription factor