Table 2.
Histomorphological characteristics of KRAS+versus KRAS−cases
| Histomorphological characteristics | KRAS positive(n=28), n(%) | KRAS negative(n=72), n(%) | P |
|---|---|---|---|
| Cellular arrangement | |||
| Solid | |||
| Present | 12(42.86) | 28(38.89) | 0.716 |
| Absent | 16(57.14) | 44(61.11) | |
| Acinar | |||
| Present | 18(64.29) | 36(50) | 0.198 |
| Absent | 10(35.71) | 36(50) | |
| Papillary/micropapillary | |||
| Present | 3(10.71) | 12(16.67) | 0.454 |
| Absent | 25(89.29) | 60(83.33) | |
| Lepidic | |||
| Present | 5(17.86) | 7(9.72) | 0.265 |
| Absent | 23(82.14) | 65(90.28) | |
| Singly scattered/loose clusters | |||
| Present | 21(75) | 61(84.72) | 0.255 |
| Absent | 7(25) | 11(15.28) | |
| Nuclear pleomorphism | |||
| Mild | 8(28.57) | 11(15.28) | 0.128 |
| Moderate orsevere | 20(71.43) | 61(84.72) | |
| Tumor differentiation | |||
| Well | 8(28.57) | 8(11.11) | 0.065 |
| Moderate | 11(39.29) | 43(59.72) | |
| Poor | 9(32.14) | 21(29.16) | |
| Mucin(extracellular or intracytoplasmic) | |||
| Present | 9(32.14) | 10(13.89) | 0.036* |
| Absent | 19(67.86) | 62(86.11) | |
| Necrosis | |||
| Present | 16(57.14) | 29(40.28) | 0.127 |
| Absent | 12(42.86) | 43(59.72) | |
KRAS: Kirsten rat sarcoma virus