TABLE 2.
Common metabolites between obese and lean models and their metabolic pattern as an effect of metformin and T2DM.
| Metabolite ID | HMDB ID | Obese cohort FC¥ (p-value) | Lean cohort FC¥ (p-value) |
|---|---|---|---|
| L-Arginine | HMDB0000517 | ↓2.08 (6.36E-5) | ↓1.65 (9.89E-3) |
| Guanidoacetic acid | HMDB0000128 | ↓2.39 (2.61E-8) | ↓2.18 (2.21E-5) |
| 5-Hydroxyindoleacetic acid | HMDB0000763 | ↑2.0 (2.47E-4) | ↓2.07 (9.22E 05) |
| L-Proline | HMDB0000162 | ↑1.98 (1.05E-5) | ↑1.63 (1.16E-02) |
| Taurine | HMDB0000251 | ↓1.62 (1.5E-4) | ↓1.89 (7.67E-4) |
| L-Alanine | HMDB0000161 | ↑1.67 (0.00045) | ↑1.85 (1.26E-3) |
| Citrulline | HMDB0000904 | ↓1.65 (0.004) | ↓2.05 (1.15E-4) |
| 5-Hydroxymethyluracil | HMDB0000469 | ↓2.25 (3.31E-6) | ↓2.35 (1.71E-6) |
| Salicylic acid | HMDB0001895 | ↑1.52 () | ↑1.61 (1.46E-2) |
FC: Fold change ↑: up-regulated or ↓: down-regulated in the metformin-treated group compared to diabetic untreated in both cohorts.¥ Regulation in metformin treated group compared to untreated in both cohorts.