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. 2021 Feb 16;12:636154. doi: 10.3389/fphar.2021.636154

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Copyright © 2021 Xiong, Deng, Wang, Shao, Zhou, Zou and Zhuang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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I-BET151 inhibits renal tubular epithelial-to-mesenchymal transition in the kidney of HN rats. (A) Kidney tissue lysates were subjected to immunoblot analysis with specific antibodies against E-cadherin, vimentin or GAPDH. (B) Expression levels of E-cadherin (B) or vimentin (C) were quantified by densitometry and normalized to GAPDH. (D) Photomicrographs (original magnification, ×400) illustrate immunohistochemical staining of E-cadherin and vimentin in in kidney tissues. Graphic presentation of quantitative data for the staining of E-cadherin (E) and vimentin (F). Data are represented as the mean ± SEM. *p < 0.05; **p < 0.01.