TABLE 3.

GESA for KEGG pathways between low- and high-TMB groups.

Group	Name	ES	NES	Nom P-value	FDR q-value
High TMB	KEGG ANTIGEN_PROCESSING_AND_PRESENTATION	0.684	1.948	0.004	0.125
Low TMB	KEGG_TIGHT_JUNCTION	–0.415	–1.654	0.014	0.221
	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	–0.570	–1.638	0.037	0.225
	KEGG_OTHER_GLYCAN_DEGRADATION	–0.655	–1.658	0.040	0.233
	KEGG_GLYCEROPHOSPHOLIPID_METABOLISM	–0.433	–1.664	0.006	0.245
	KEGG_BLADDER_CANCER	–0.440	–1.513	0.034	0.247

ES, enrichment score; NES, normalized enrichment score; NOM P-value, normalized P-value; FDR q-value, false discovery rate q-value.