TABLE 4.

GESA for GO analysis between low- and high-TMB groups.

Group	Name	ES	NES	Nom P-value	FDR q-value
GO_CC TMB High	GO_POSTSYNAPTIC_CYTOSOL	0.587	1.629	0.033	0.245
GO_CC TMB Low	GO_LATERAL_PLASMA_MEMBRANE	–0.604	–2.093	0	0.069
	GO_APICOLATERAL_PLASMA_MEMBRANE	–0.728	–2.040	0	0.081
	GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX	–0.701	–1.944	0.006	0.189
	GO_MULTIVESICULAR_BODY	–0.554	–1.817	0.004	0.231
	GO_DENDRITIC_SPINE_MEMBRANE	–0.702	–1.706	0.006	0.245
GO_BP TMB High	GO_MITOTIC_SISTER_CHROMATID_SEGREGATION	0.654	2.125	0.002	0.062
	GO_NEGATIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE	0.751	2.166	0	0.066
	GO_RESPONSE_TO_UV_C	0.751	2.135	0	0.070
	GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION	0.727	2.192	0	0.084
	GO_REGULATION_OF_CHROMOSOME_SEGREGATION	0.636	2.045	0.006	0.100
GO_BP TMB Low	GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT	–0.626	–1.911	0.008	0.240
	GO_ENERGY_RESERVE_METABOLIC_PROCESS	–0.494	–1.917	0	0.243
	GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT	–0.730	–2.099	0	0.245
	GO_RENAL_SODIUM_EXCRETION	–0.685	–1.912	0.002	0.245
	GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY	–0.731	–1.919	0.008	0.248
GO MF TMB High	GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_BINDING	–0.817	–2.199	0	0.020
	GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING	–0.689	–2.062	0	0.064
	GO_ACTIVIN_BINDING	–0.765	–1.950	0	0.104
	GO_LYSOPHOSPHOLIPASE_ACTIVITY	–0.676	–1.958	0	0.111
	GO_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	–0.640	–1.971	0	0.119

ES, enrichment score; NES, normalized enrichment score; NOM P-value, normalized P-value; FDR q-value, false discovery rate q-value.