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. 2021 Feb 12;24(3):102183. doi: 10.1016/j.isci.2021.102183

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Ultrastructural characterization of neurons and microglia in 5-cell spheroids

Representative STEM micrographs showing (A) part of a neuronal cytoplasm and the presence of Golgi apparatus, (B) neuronal fractions, the primary neural specific cilium lined on the surface of the spheroid, Golgi apparatus, endoplasmic reticulum, and ribosomes, (C) a myelinated sheath in the spheroids along with electron-dense Nissl bodies of the neuronal cytoplasm (indicated with dotted circles), (D) microglia with thicker heterochromatin grains that stand out in the nucleus and the neuronal junctions, (E) lipid bodies characteristic of microglia, (F) neuronal processes and release of synaptic vesicles (black arrow), (G) microglial processes connecting specialized areas of the neuronal cytoplasm, (H) endothelial cell process extending to form a junction with an overlying pericyte, and (I) neuronal cytoplasm containing characteristic features such as the oval-shaped nucleus of a neuron containing the nucleolus, neuronal perikaryal contains multivesicular bodies (small black dots around), mitochondria, and Golgi apparatus.