Figure 8.

STEM micrographs of 5-cell spheroids exposed to different metallic and carbonaceous nanoparticles

(A and B) Au NPs inside microglia (indicated with yellow arrows) and surrounding endosomes and lysosomes. Cells display characteristic lipid droplets (indicated with yellow dotted arrows).

(C) Ag NPs inside vesicles (indicated with yellow dotted circle) of microglia displaying characteristic lipid droplets.

(D and E) (D) Ag NPs inside microglia clusters, (E) Ag NPs inside endosomes and lysosomes of glia (indicated with yellow dotted circle).

(F) Cell disruption effect of graphene nanoplates on astrocytes (indicated with a yellow arrow in the insert).

(G) Cell destructive effect of alkaline carbon dots on a 5-cell spheroid.