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. 2021 Feb 4;11:621043. doi: 10.3389/fimmu.2020.621043

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Copyright © 2021 Dussupt, Modjarrad and Krebs

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutralizing epitopes of Zika virus (ZIKV) and dengue virus (DENV) monoclonal antibodies. Top, Characteristics of prototypical ZIKV and DENV neutralizing antibodies grouped by epitope specificities. Neutralization potency is based on IC50 against ZIKV unless otherwise indicated. IC50 (ng/ml) are indicated as follows: **** (<10 ng/ml); *** (10–50 ng/ml); ** (50–500 ng/ml); * (>500 ng/ml). Bottom, the same neutralizing epitopes mapped onto the ZIKV E dimer. The ZIKV E dimer, PDB 5LBV (25), is shown in ribbon representation with the respective domains of each protomer colored in red (DI), yellow (DII), and blue (DIII) while the fusion loop in DII is highlighted in green. This visual was generated using UCSF Chimera (48).