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. 2021 Feb 4;11:621043. doi: 10.3389/fimmu.2020.621043
Virus Prototypical antibody Similar antibodies Species Source, isolation strategy Epitope,critical residues Neutralizationpotency Cross neutralization References
Fusion loop ZIKV-DENV 2A10G6 4G2 mouse DENV-2 immunized mouse, hybridoma screening Fusion loop
W101
* ZIKV, DENV1-4, WNV (1719)
ZIKV-DENV MZ54 MZ56 human Flavivirus-experienced ZIKV vaccinee, B cell sort using whole virus + ZIKV/DENV E probes Fusion loop
W101
** ZIKV, DENV1-4, WNV (20)
DI/DII ZIKV Z3L1 human ZIKV-infected human, memory B cell sort using ZIKV E probe DI, DI-DII hinge ** ZIKV specific (21)
DENV-1 1F4 human B cells from DENV immune human, screening of EBV-transformed B cells from total PBMCs DI, DI-DII hinge *** DENV-1 specific (22, 23)
DII ZIKV-DENV MZ20 1C19 human Flavivirus-experienced ZIKV vaccinee, B cell sort using whole virus + ZIKV/DENV E probes DII bc loop
R73
** ZIKV, DENV1-4, JEV (20, 24)
E dimer ZIKV/DENV EDE1-C8 EDE1-B10, C10, EDE2-A11 human Patients with acute DENV infection, screening of total plasmablasts E dimer
M68, S70, S72, G104, Q253, T315
*** (C8)
**** (B10)
ZIKV, DENV1-4 (2530)
DENV-2 2D22 human B cells from DENV immune human, screening of EBV-transformed B cells from total PBMCs E dimer ** (DENV-2) DENV-2 specific (21, 31)
DIII lateral ridge ZIKV ZV-67 ZV-54 mouse ZIKV-infected mouse with EDIII boost, hybridoma screening DIII lateral ridge
K394
** ZIKV specific (32)
ZIKV/DENV-1 Z004 Z006, 1C11, ZIKV-116, SMZAb5 human B cell from a ZIKV-infected human, memory B cell sort using ZIKV EDIII probe DIII lateral ridge
E393, K394
**** ZIKV, DENV-1 (3337)
DENV-1 E105 E106 mouse DENV-1 infected mouse with EDIII boost, hybridoma screening DIII lateral ridge *** DENV-1 specific (38)
DENV-2 3H5 2C8 mouse DENV-2 infected mouse, hybridoma screening DIII lateral ridge **** DENV-2 specific (39, 40)
ZIKV ZKA190 human B cell from a ZIKV-infected human, EBV-transformed B cell from total memory B cells DI-DIII linker, DIII lateral ridge *** ZIKV specific (41, 42)
DI/DIII linker ZIKV/DENV MZ4 MZ1, MZ2, MZ24 human Flavivirus-experienced ZIKV vaccinee, B cell sort using whole virus + ZIKV/DENV E probes DI-DIII linker
Y305
**** ZIKV, DENV1-4 (20)
DENV-4 5H2 chimpanzee Phage display from repertoire of infected chimpanzee DI, DI-DIII linker ** (DENV-4) DENV-4 specific (43, 44)
Quaternary ZIKV ZIKV-117 human B cell from a ZIKV-infected human, screening of EBV-transformed B cells from total PBMCs dimer-dimer interface
D67, Q89, K118
**** ZIKV specific (45, 46)
DENV-3 5J7 human B cells from DENV immune human, screening of EBV-transformed B cells from total PBMCs Quaternary DI-DII hinge, DII, DIII on 3 different protomers **** DENV-3 specific (22, 47)