Figure 8.
The effect of HIV-1 gp120 on cortical and spinal microglial nervous signaling pathways
(A) Importing the upregulated list of genes of each cluster into Ingenuity Pathway Analysis (IPA) predicted the activated nervous signaling pathways of cortical microglia in the two-, four-, and eight-month-old Wt cortices.
(B) The activated cortical microglial signaling was severely suppressed by gp120 in the Tg brain cortices at all ages.
(C) IPA predicted the activated nervous signaling pathways of spinal microglia in the two-, four-, and eight-month-old Wt spinal cords. (D) The activated nervous signaling of spinal microglia was differentially attenuated by gp120 in the Tg spinal cords. Note the signaling of spinal microglia was attenuated in a less degree compared to that of the cortical microglia. Orange: activated signaling. Blue: inhibited signaling. Dot: not significantly changed.