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. 2020 Oct 23;29(2):175–183. doi: 10.4062/biomolther.2020.112

Fig. 2.

Fig. 2

HO-1 overexpression suppresses the MAPK signaling pathway in Caco-2 cells. Caco-2 cells were transfected with FUGW-HO-1 or pLKO.1-sh-HO-1 plasmid, and cells transfected with empty plasmid as the control groups. (A, B) The representative protein bands and the ratios of p-ERK/ERK, p-p38/p38, and p-JNK/JNK in Caco-2 cells transfected with FUGW-HO-1 or empty plasmid, as measured by Western blot analysis. (C, D) The representative protein bands and the ratios of p-ERK/ERK, p-p38/p38, and p-JNK/JNK in Caco-2 cells transfected with pLKO.1-sh-HO-1, as measured by Western blot analysis. Measurement data are expressed as mean ± SD. All data presented were representative of three or more independent experiments, each with similar results. Bar *p<0.05, **p<0.01, and ***p<0.001.