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. 2021 Feb 6;47:101185. doi: 10.1016/j.molmet.2021.101185

Figure 7.

Figure 7

Distinct effects of EGFR activation and UVRAG deletion in skeletal muscle function. (A) Grip strength measurement of 6-month-old male mice (n = 9–11). (B) Representative H&E staining (left) and quantification of central nuclei (right) from tibialis anterior muscle at 6 months of age (n = 6). Central nuclei are indicated by arrows. Scale bar, 50 μm. (C) Relative expression of myosin heavy-chain (MHC) subtypes in tibialis anterior muscle of the 6-month-old male mice (n = 5–6). (D) Relative expression of genes related to mitochondrial deregulation (Fgf21 and Gdf15), mitochondrial biogenesis (Tfb1m and Tfb2m), mitochondrial oxidative phosphorylation (Cycs and Ndufb5), and muscle function (Pgc1α and Glut4) from tibialis anterior of the 6-month-old male mice (n = 5–7). Data shown are mean ± S.E.M. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001 using one-way ANOVA with Tukey's post hoc test.