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. 2021 Feb 1;10:60. [Version 1] doi: 10.12688/f1000research.28318.1

Table 1. Results of the test of association between haplotypes of the N-terminal esxH epitope and the geographic region of origin.

Region 1 Strains 2 Association 3 esxH (A10V) 4 esxH (A10X) 5 esxH (N terminus) 6
Strains p-value Strains p-value Strains p-value
South Asia 219 + 1 0.4852 6 0.385 17 0.453
Southeast Asia (islands) 235 + 10 0.154 156 0.081 171 0.174
Southeast Asia (mainland) 982 + 25 0.200 183 0.095 210 0.196
East Africa 466 - 0 0.046 1 0.034 29 0.276
East Africa (no Madagascar) 391 - 0 0.070 0 0.018 1 0.0004
South Africa 49 - 0 0.305 0 0.165 0 0.013
South America 77 - 0 0.496 0 0.352 0 0.095

1 We included only regions for which the sample size was 25 or more.

2 Total number of L1 strains from each region.

3 All p-values are one-tailed empirical p-values. This column indicates the direction of the association: + we tested for positive association between the derived haplotype(s) and the geographic region; - we tested for negative association between derived haplotype(s) and the geographic region.

4 Number of strains with the derived haplotype caused by the replacement A10V, and results of the test of association. P-values < than 0.1 are shown in bold.

5 Number of strains with the derived haplotypes caused by any replacement at position 10 (A10X), and results of the test of association. P-values < than 0.1 are shown in bold.

6 Number of strains with the derived haplotypes caused by any mutations occurred in the first 18 amino acids of EsxH, and results of the test of association. P-values < than 0.1 are shown in bold.